Endocrine Abstracts

Two growth hormone releasing hormone-like peptides (GHRH-LP-1 and GHRH-LP-2) are expressed in chickens. Although GHRH-LP-1 displaces the binding of labelled human GHRH to chicken pituitary membranes and stimulates the accumulation of cAMP in HEK 293 cells transfected with the chicken (c) GHRH receptor it has <1% of the potency of human GHRH1–32 and has little, if any, growth hormone (GH) - releasing activity in chickens. GHRH-LP-1 is thus unlikely to be the...